DİYABETİK YARALARIN YÖNETİMİNDE KULLANILAN BİTKİSEL TEMELLİ ALTERNATİF TEDAVİ YAKLAŞIMLARI

Altan, A. (2015): Diyabetik ratlarda kantaronun (Hypericum perforatum) ağız mukozasındaki yara iyileşmesine etkisi. Gaziantep Üniversitesi, Diş Hekimliği Fakültesi, Sağlık Bilimleri Enstitüsü, Gaziantep, Türkiye.

Polat, N. (2023): Diyabetik rat yara modelinde Lucilia sericata larvaları ve Achillea sintenisii ekstraktlarının kombine kullanımında yara iyileştirici aktivitelerinin histopatolojik olarak araştırılması. Ankara Yıldırım Beyazıt Üniversitesi, Halk Sağlığı Enstitüsü, Biyoenformatik Ana Bilim Dalı, Ankara, Türkiye.

Oguntibeju, O. O. (2019): Medicinal plants and their effects on diabetic wound healing. Veterinary World, 12: 653-663.

Criollo-Mendoza, M. S., Contreras-Angulo, L. A., Leyva-López, N., Gutiérrez-Grijalva, E. P., Jiménez-Ortega, L. A., Heredia, J. B. (2023): Wound healing properties of natural products: mechanisms of action. Molecules 28: 598.

Aydın, A. (2017): Streptozotosin ile diyabet oluşturulan sıçanlarda nar çekirdeği yağının yara iyileşmesi üzerine etkileri Erciyes Üniversitesi, Tıp Fakültesi, Plastik Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı, Kayseri, Türkiye.

Yazarlu, O., Iranshahi, M., Kashani, H. R. K., Reshadat, S., Habtemariam, S., Iranshahy, M., Hasanpour, M. (2021): Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review. Pharmacological Research 174: 105841.

Wilkinson, H. N., Hardman, M. J. (2020): Wound healing: cellular mechanisms and pathological outcomes. Open Biology 10: 200223.

Gowda, B. H. J., Mohanto, S., Singh, A., Bhunia, A., Abdelgawad, M. A., Ghosh, S., Pramanik, S. (2023): Nanoparticle-based therapeutic approaches for wound healing: A review of the state-of-the-art. Materials Today Chemistry 27: 101319.

Öztopalan, D. F., Işık, R., Durmmuş, A. S. (2017): Yara iyileşmesinde büyüme faktörleri ve sitokinlerin rolü. Dicle Üniversitesi Veteriner Fakültesi Dergisi 10: 83-88.

Ansari, P., Akther, S., Khan, J. T., Islam, S. S., Masud, M. S. R., Rahman, A., Abdel-Wahab, Y. H. (2022): Hyperglycaemia-linked diabetic foot complications and their management using conventional and alternative therapies. Applied Sciences 12: 11777.

IDF 2019. Diabetes Atlas. Erişim Tarihi: 12 Mayıs 2025. https://www.diabetesatlas.org/en/

Herman, A., Herman, A. P. (2023): Herbal products and their active constituents for diabetic wound healing-Preclinical and clinical studies: A systematic review. Pharmaceutics 15: 281.

Yadav, J. P., Singh, A. K., Grishina, M., Pathak, P., Verma, A., Kumar, V., Patel, D. K. (2024): Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies. Inflammopharmacology 32: 149-228

Zhang, P., Lu, J., Jing, Y., Tang, S., Zhu, D., Bi, Y. (2017): Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Annals of Medicine 49: 106-116.

Chakraborty, R., Borah, P., Dutta, P. P., Sen, S. (2022): Evolving spectrum of diabetic wound: mechanistic insights and therapeutic targets. World Journal of Diabetes 13: 696.

Chauhan, S., Chalotra, R., Rathi, A., Saini, M., Deol, S., Lard, M., Gupta, S. (2023): Current approaches in healing of wounds in diabetes and diabetic foot ulcers. Current Bioactive Compounds 19: 104-121.

Kim, J. (2023): The pathophysiology of diabetic foot: a narrative review. Journal of Yeungnam Medical Science 40: 328-334.

Kumar, S., Bharali, A., Sarma, H., Kushari, S., Gam, S., Hazarika, I., Prasad, S. K., Laloo, D. (2023): Traditional complementary and alternative medicine (TCAM) for diabetic foot ulcer management: A systematic review. Journal of Ayurveda and Integrative Medicine 14: 100745.

Narzary, I., Swarnakar, A., Kalita, M., Middha, S. K., Usha, T., Babu, D., Mochahary, B., Brahma, S., Basumatary, J., Goyal, A. K. (2023): Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review. World Journal of Clinical Cases, 11: 4035–4059.

Aladejana, E. B., Adelabu, O. A., Aladejana, A. E., Ndlovu, S. I. (2024): Antimicrobial properties of alternative medicines used in the management of infections in diabetic patients: A comprehensive review. Pharmacological Research-Modern Chinese Medicine 100432.

Xu, Z., Dong, M., Yin, S., Dong, J., Zhang, M., Tian, R., Min, W., Zeng, L., Qiao, H., Chen, J. (2023): Why traditional herbal medicine promotes wound healing: Research from immune response, wound microbiome to controlled delivery. Advanced Drug Delivery Reviews 195: 114764.

Gorain, B., Pandey, M., Leng, N. H., Yan, C. W., Nie, K. W., Kaur, S. J., Choudhury, H. (2022): Advanced drug delivery systems containing herbal components for wound healing. International Journal of Pharmaceutics 617: 121617.

Pathak, D., Mazumder, A. (2024): A critical overview of challenging roles of medicinal plants in improvement of wound healing technology. DARU Journal of Pharmaceutical Sciences 32: 379-419.

Krishnan K, A., Thomas, S. (2019): Recent advances on herb‐derived constituents‐incorporated wound‐dressing materials: A review. Polymers for Advanced Technologies 30: 823-838.

Cedillo-Cortezano, M., Martinez-Cuevas, L. R., López, J. A. M., Barrera López, I. L., Escutia-Perez, S., Petricevich, V. L. (2024): Use of medicinal plants in the process of wound healing: a literature review. Pharmaceuticals 17: 303.

Hashemi, S. S., Rezaeian, R., Rafati, A., Sanati, P., Mehrabani, D., Malekshah, R. E., Khonakdar, H. A. (2024): A review on application of herbals and their polymer composites in wound healing. Arabian Journal of Chemistry 17: 105820.

Wurz, J. (2019): The wound healing effects of a 3 CH homeopathic solution of hypericum perforatum, calendula officinalis and echinacea purpurea combied with photobiomodulation on diabetic fibroblasts. University of Johannesburg, Faculty of Health Sciences, Johannesburg, South Africa.

Fattahi, A., Niyazi, F., Shahbazi, B., Farzaei, M. H., Bahrami, G. (2017): Antidiabetic mechanisms of Rosa canina fruits: an in vitro evaluation. Journal of Evidence-Based Complementary & Alternative Medicine, 22: 127-133.

Samancıoğlu, S., Esen, A., Ercan, G., Mansoub, N. H., Vatansever, S., İnce, İ. (2016): A new dressing material in diabetic wounds: Wound healing activity of oleuropein-rich olive leaf extract in diabetic rats. European Journal of Therapeutics 22: 14-21.

Abu-Al-Basal, M. A. (2010): Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice. Journal of Ethnopharmacology 131: 443-450.

Jia, Y., Zhao, G., Jia, J. (2008): Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing. Journal of Ethnopharmacology 120: 181-189.

Tamilarasi, G. P., Krishnan, M., Sabarees, G., Gouthaman, S., Alagarsamy, V., Solomon, V. R. (2022): Emerging trends in curcumin embedded electrospun nanofibers for impaired diabetic wound healing. Applied Nano 3: 202-232.

Alghamdi, S. A., Alissa, M., Alsuwat, M. A. (2024): Dermal derived matrix hydrogel loaded with curcumin improved wound healing in a diabetic rat model. Tissue and Cell 90: 102495.

Berk, A., Dokumacı, A. H., Kaymaz, M. B. (2015): Yara iyileşmesi ve diyabetik yara tedaviside kullanılan tıbbi bitkiler. Sağlık Bilimleri Dergisi 24: 185–192.

Sidhu, G. S., Mani, H., Gaddipati, J. P., Singh, A. K., Seth, P., Banaudha, K. K., Patnaik, G. K., Maheshwari, R. K. (1999): Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair and Regeneration 7: 362–374.

Razif, R., Fadilah, N. I. M., Ahmad, H., Looi Qi Hao, D., Maarof, M., Fauzi, M. B. (2025): Asiaticoside-Loaded Multifunctional Bioscaffolds for Enhanced Hyperglycemic Wound Healing. Biomedicines 13: 277.

Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2013): Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 30: 46-49.

Paocharoen, V. (2010): The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients. Journal of the Medical Association of Thailand 93:166-170.

Araujo-Filho, I., da Silva, F. B., Gonçalves, G. F., do Rêgo, A. C. M. (2023): Pomegranate (Punica Granatum L) And Wound Healing: A Review of Experimental Studies. Journal Of Surgical and Clinical Research 14: 63-72.

Ahmad, A., Husain, A., Mujeeb, M., Siddiqui, N. A., Damanhouri, Z. A., Bhandari, A. (2014): Physicochemical and phytochemical standardization with HPTLC fingerprinting of Nigella sativa L. seeds. Pakistan Journal of Pharmaceutical Sciences 27: 5.

Betul, A. Y., Semin, G. (2019): Wound healing effects of Nigella sativa L. essential oil in streptozotocin induced in diabetic rats. GSC Biological and Pharmaceutical Sciences 7: 30-40.

Sari, Y., Purnawan, I., Kurniawan, D. W., Sutrisna, E. (2018): A Comparative Study of the Effects of Nigella sativa Oil Gel and Aloe vera Gel on Wound Healing in Diabetic Rats. Journal of Evidence-Based Integrative Medicine 23: 1-6.

Muley, B. P., Khadabadi, S. S., Banarase, N. B. (2009): Phytochemical Constituents and Pharmacological Activities of Calendula officinalis Linn (Asteraceae): a Review. Tropical Journal of Pharmaceutical Research 8: 5.

Pazyar, N., Yaghoobi, R., Rafiee, E., Mehrabian, A., Feily, A. (2014): Skin wound healing and phytomedicine: a review. Skin Pharmacology and Physiology 27: 303-310.

Givol, O., Kornhaber, R., Visentin, D., Cleary, M., Haik, J. Harats, M. (2019): A systematic review of Calendula officinalis extract for wound healing. Wound Repair and Regeneration, 27: 548-561.

Salami, M. S., Bahrami, G., Arkan, E., Izadi, Z., Miraghaee, S., Samadian, H. (2021): Co-electrospun nanofibrous mats loaded with bitter gourd (Momordica charantia) extract as the wound dressing materials: in vitro and in vivo study. BMC Complementary Medicine and Therapies 21: 1-12.

Joseph, B., Jini, D. (2013): Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pacific Journal of Tropical Disease 3: 93-102.

Ono, T., Tsuji, T., Sakai, M., Yukizaki, C., Ino, H., Akagi, I., Gohda, E. (2009): Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp. Cytokine 46: 119-126.

Al-hashimi, H. T., Merie, G. M. S., & Saadi, A. M. (2025): The Therapeutic Potential of Aqueous Extract of Fig Leaves in the Management of Diabetic Foot Ulcers. International Journal of Multidisciplinary Research and Growth Evaluation 6: 552-559.

Khan, A. D., Rastogi, V., Lavhale, P., Jain, J. (2022): Novel Approaches for Herbal Drug Delivery in Wound Healing: A Review. Indian Journal of Pharmaceutical Sciences 84: 2.

Baidya, R., Sarkar, B. (2024): A systematic review of the traditional uses, chemistry, and curative aptitude of echinacoside—a phenylethanoid glycoside. Naunyn-Schmiedeberg's Archives of Pharmacology 398: 2071-2106

Hudson, J. B. (2012): Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. BioMed Research International 2012: 769896.

Husain, G. M., Singh, P. N., Kumar, V. (2009): Beneficial effects of a standardized Hypericum perforatum extract in rats with experimentally induced hyperglycemia. Drug Discoveries & Therapeutics 3: 5.

Beheshti, A. S., Qazvini, M. M., Abeq, M., Abedi, E., Fadaei, M. S., Fadaei, M. R., Askari, V. R. (2024): Molecular, cellular, and metabolic insights of cinnamon (Cinnamomum zeylanicum) advantages in diabetes and related complications: condiment or medication?. Naunyn-Schmiedeberg's Archives of Pharmacology 398: 3513-3526.

Ranasinghe, P., Pigera, S., Premakumara, G. S., Galappaththy, P., Constantine, G. R., Katulanda, P. (2013): Medicinal properties of ‘true’cinnamon (Cinnamomum zeylanicum): A Systematic Review. BMC Complementary and Alternative Medicine 13: 1-10.

Akilen, R., Tsiami, A., Devendra, D., & Robinson, N. (2012): Cinnamon in glycaemic control: Systematic review and Meta analysis. Clinical Nutrition 31: 609-615.

Kartini, K., Wati, N., Gustav, R., Wahyuni, R., Anggada, Y. F., Hidayani, R., Putra, S. E. D. (2021): Wound healing effects of Plantago major extract and its chemical compounds in hyperglycemic rats. Food Bioscience 41: 100937.

Colobatiu, L., Gavan, A., Potarniche, A. V., Rus, V., Diaconeasa, Z., Mocan, A., Mihaiu, M. (2019): Evaluation of bioactive compounds-loaded chitosan films as a novel and potential diabetic wound dressing material. Reactive and Functional Polymers 145: 104369.

Zubair, M., Widén, C., Renvert, S., Rumpunen, K. (2019): Plantago major yapraklarının su ve etanol özütleri, oral epitel hücreleri üzerinde anti-inflamatuar aktivite göstermektedir. Geleneksel ve Tamamlayıcı Tıp Dergisi , 9: 169-171.

Sharifa, A. A., Neoh, Y. L., Iswadi, M. I., Khairul, O., Abdul Halim, M., Jamaludin, M., Hing, H. L. (2008): Effects of methanol, ethanol and aqueous extract of Plantago major on gram positive bacteria, gram negative bacteria and yeast. Annals of Microscopy 8: 42-44.

Velasco-Lezama, R., Tapia-Aguilar, R., Román-Ramos, R., Vega-Avila, E., Pérez-Gutiérrez, MS (2006): Plantago major'un in vitro hücre proliferasyonu üzerindeki etkisi. Etnofarmakoloji Dergisi 103: 36-42.